Selected Publications from
Wood Hudson Cancer Research Laboratory

Studies of potential biomarkers for cancer diagnosis and prognosis and targets for therapy

Carter JH, Deddens JA, Mueller G, Lewis TG, Dooley MK, Robillard MC, Frydl M, Duvall L, Pemberton JO, Douglass LE. Transcription factors WT1 and p53 combined: a prognostic biomarker in ovarian cancer. British J. Cancer, 2018. https://www.nature.com/articles/s41416-018-0191-x

Carter JH, Deddens JA, Muller G, Lewis TG, Dooley MK, Pemberton JO, Douglass LE. Evidence for WT1 as a potential target for immunotherapy of ovarian cancer. Proc. Amer. Assoc. Cancer Res. 58:712-713, 2017.

Uhlik MT, Liu J, Falcon BL, Lyer S, Stewart J, Celikkaya H, O’Mahony M, Sevinsky C, Lowes C, Douglass L, Jeffries C, Bodenmiller D, Chintharlapalli S, Fisch A, Gerald D, Xue Q, Lee J, Santamaria-Pang A, Al-Kofahi Y, Sui Y, Desai K, Doman T, Aggarwal A, Carter, JH, Pytowski B, Jaminet S, Ginty F, Nasir A, Nagy JA, Dvorak HF, Benjamin LE. Stromal-based Signatures for the Classification of Gastric Cancers. Cancer Research 76:2573-2586, 2016. https://cancerres.aacrjournals.org/content/76/9/2573

Carter J.H., J.A. Deddens, N.R. Spaulding, D. Lucas, B.M. Colligan, T.G. Lewis, E. Hawkins, J. Jones, J.O. Pemberton, L.E. Douglass, J.R. Graff. Phosphorylation of eIF4E Serine 209 is Associated with Tumor Progression and Reduced Survival in Malignant Melanoma. British J. Cancer 114:444-453; doi:10.1038/bjc.2015.450, 2016. https://www.nature.com/articles/bjc2015450

Fajardo, A.M., T. Browne, H. Graff, K. Kleier, K. Neltner, C. McCall, B. Meyer, L.E. Douglass and J.H. Carter. Targeting PAK 1 activity in breast cancer: Inhibition of cell growth, survival, motility, and signaling. Cancer Research 75:1024; doi:10.1158/1538-7445.AM2015-1024, 2015.

Carter, J.H., N.R. Spaulding, B.M. Colligan, J.A. Deddens and L.E. Douglass. Overexpression of PAK 1 is a favorable prognostic biomarker in malignant melanoma. Cancer Research 73:22; doi:10.1158/1538-7445.AM2013-22, 2013

Thobe, M.N., S.B. Yan, K.M. Credille, A. Nasir, J.A Roseberry Baker, M. Lajiness, N.A. Brooks, D.W. Ballard, D.M. Farley, V.L. Peek, S.L. Um, G.J. Jin, R. Gilmour, C. Reinhard, J.R. Graff, A.E. Schade, A.M. Gruver, B.M. Colligan, L.E. Douglass, J.H. Carter and R.A. Walgren. Prevalence of MET expression, activating mutations of KRAS and IDH1/2, and ROS1 fusions in cholangiocarcinoma patient tumor samples. Cancer Research 73:2339; doi:10.1158/1538-7445.AM2013-2339, 2013

Carter, J.H., K. Murray, J. Bender, H. Restle, S. Mulvihill, B.M. Colligan, J.A. Deddens, J.P. Schaeper and L.E. Douglass. TGFβR1 germline variant Int7G24A but not TGFβR1*6 increases risk for colon cancer. Cancer Research 72:1153; doi:10.1158/1538-7445.AM2012-1153, 2012

Carter, J.H., L.E. Douglass, J.A. Deddens, B.M. Colligan, B.M. Hurst, J. Pullman, R.E. Richmond and H.W. Carter. Overexpression of Cathepsin L is associated with prostate cancer development, progression, and reduced patient survival. Cancer Research 71:4172; doi: 10.1158/1538-7445.AM2011-4172, 2011.

Schaeper, J.P., K. Murray, J.L. DeBrosse, B. Vogt, D. Lucas, B.M. Colligan, J.A. Deddens, L.E. Douglass, J.R. Graff and J.H. Carter. Association of germline variants of the TGFβR1 gene in colorectal cancer patients. Cancer Research 70:1183; doi: 10. 1158/1538-7445.AM10-1183, 2010.

Schaeper, J.P., T. Chen, M. Markey, R. Shields, K. Bree, B. Kohrs, C. Baldwin, B.M. Colligan, J.A. Deddens, J.R. Graff, L.E. Douglass and J.H. Carter. Germline homozygous TGFβR1 variant Int7G24A genotype is significantly related to patients ovarian cancer progression. Cancer Research 69:5615, 2009.

Carter, J.H., J.R. Graff, J. Schaeper, D. Nardini, M. Love, B.M. Colligan, J.A. Deddens and L.E. Douglass. Translation initiation factor eIF4E increases during uterine cervical cancer progression to metastasis and is correlated with cell proliferation. Cancer Research 69:5558, 2009.

Douglass, L.E., J.A. Deddens, B.M. Colligan, D. Lucas, A. Foertsch, J.R. Graff and J.H. Carter. β-Catenin in human colorectal cancer development, progression, metastasis and survival. Cancer Research 69:1652, 2009.

Graff, J.R., B.W. Konicek, R.L. Lynch, C.A. Dumstorf, M. Dowless, A.M. McNulty, S. Parsons, L. Brail, B.M. Colligan, J.W. Koop, B.M. Hurst, J.A. Deddens, B.L. Neubaurer, L.F. Stancato, H.W. Carter, L.E. Douglass and J.H. Carter. eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Is Significantly Related to Reduced Patient Survival. Cancer Research, 69: (9) 3866-73, 2009.
http://cancerres.aacrjournals.org/content/69/9/3866.full

Graff, Jeremy R., B.W. Konicek, J.H. Carter, and E.G. Marcusson. Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy. Cancer Res. 68: (3) 631-634, 2008.
http://cancerres.aacrjournals.org/content/68/3/631.full

Graff, J.R., B.W. Konicek, T.M. Vincent, R.L. Lynch, D. Monteith, S.N. Weir, P. Schwier, A. Capen, R.L. Goode, M.S. Dowless, Y. Chen, H. Zhang, S. Sissons, K. Cox, A.M. McNulty, T. Wang, L. Sams, S. Geeganage, L.E. Douglass, B.L. Neubauer, N.M. Dean, K. Blanchard, J. Shou, L.F. Stancato, J.H. Carter, and E.G. Marcusson. Therapeutic Suppression of Translation Initiation Factor eIF4E Expression Reduces Tumor Growth without Toxicity. J. Clin. Invest. 117:2638-2648, 2007. https://www.jci.org/articles/view/32044

Chen, T., C.R. Jackson, A. Link, M.P. Markey, B.M. Colligan, L.E. Douglass, J.O. Pemberton, J.A. Deddens, J.R. Graff, and J.H. Carter, Int7G24 Variant of Transforming Growth Factor Beta Type 1 Receptor is Associated with Invasive Breast Cancer. Clin. Cancer Res. 12:392-397, 2006.
http://clincancerres.aacrjournals.org/content/12/2/392.full

Chen, T., C. Jackson, B. Costello, N. Singer, B. Colligan, L. Douglass, J. Pemberton, J. Deddens, J.R. Graff, and J.H. Carter. An Intronic Variant of the TGFBR1 Gene is Associated with Carcinomas of the Kidney and Bladder. Internatl. J. Cancer, 112:420-425, 2004. https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.20419

Carter, J.H., L.E. Douglass, J.A. Deddens, B.M. Colligan, T.R. Bhatt, J.O. Pemberton, S. Konicek, J. Hom, M. Marshall, and J.R. Graff. Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis. Clin. Cancer Res., 10:3448-3456, 2004.
http://clincancerres.aacrjournals.org/content/10/10/3448.full

Graff, J.R., B.W. Konicek, J.A. Deddens, M. Chedid, B.M. Hurst, B. Colligan, B.L. Neubauer, H.W. Carter, and J.H. Carter. Expression of Group Iia Secretory Phospholipase A2 Increases with Prostate Tumor Grade. Clin. Cancer Res., 7:3857-3861, 2001.
http://clincancerres.aacrjournals.org/content/7/12/3857.full

Graff, J.R., J.A. Deddens, B.W. Konicek, B.M. Colligan, B. M. Hurst, H.W. Carter, and J.H. Carter. Integrin-linked Kinase Expression Increases with Prostate Tumor Grade. Clin. Cancer Res. 7:1987-1991, 2001.
http://clincancerres.aacrjournals.org/content/7/7/1987.full

Chen, T., J. Triplett, B. Dehner, B. Hurst, B. Colligan, J. Pemberton, J.R. Graff, and J.H. Carter. Transforming Growth Factor- Receptor Type I Gene is Frequently Mutated in Ovarian Carcinomas. Cancer Research 61:4679-4682, 2001.
http://cancerres.aacrjournals.org/content/61/12/4679.full

Carter, J.H., J.A. Deddens, J.L. Pullman, B.M. Colligan, L.O. Whiteley, and H.W. Carter, Validation of the Galactose Oxidase-Schiff’s Reagent Sequence for Early Detection and Prognosis in Human Colorectal Adenocarcinoma. Clin. Can. Res. 3:1479-1489, 1997.
http://clincancerres.aacrjournals.org/content/3/9/1479.full.pdf+html

Richmond, R.E, J.H. Carter, H.W. Carter, I.J. Magrisso, C. Pross and R. Gilfillen, Immunohistochemical Detection of Ras, Jun, Fos and P53 Oncoprotein Expression in Human Colorectal Adenomas and Carcinomas. Lab. Invest., 69:674-681, 1993.

Studies of cancer causing potential of environmental chemicals

Wehmas LC, DeAngelo AB, Hester SD, Chorley BN, Carswell G, Olson GR, George M, Carter JH, Eldridge SR, Fisher A, Vallanat B, Wood CE. Metabolic disruption early in life is associated with latent carcinogenesis of dichloroacetic acid in mice. Toxicological Sciences 159:354-365; doi: 10.1093/toxsci/kfx146, 2017.

Wood C.E., M.P. Jokinen, C.L. Johnson, G. R. Olson, S. Hester, M. George, A.N. Chorley, G. Carswell, J.H. Carter, C. R. Wood, V. S. Bhat, J.C. Corton, A.B. DeAngelo. Comparative Time Course Profiles of Phthalate Stereoisomers in Mice. Toxicological Sciences: 139:21-34; 2014, doi:10.1093/toxsci/kfu025, 2014. https://academic.oup.com/toxsci/article-abstract/139/1/21/1670725?redirectedFrom=fulltext

Carter, J.H., S. Vogelpohl, M.K. Tucker, and R. Tagher. Sub-lethal autolysis in livers of mice given phthalate esters precedes development of hepatic lesions. Cancer Research 74:3185; doi: 10. 1158/1538-7445. AM2014-3185, 2014

Carter, J.H., H.W. Carter, R.E. Richmond, J.A. Deddens, N. Chiu, and A.B. DeAngelo. Cell proliferation and apoptosis during chloroform-induced hepatocarcinogenesis in male F-344/N rats. Cancer Research 70:341; doi: 10. 1158/1538-7445.AM10-3451, 2010

Carter, J.H., H.W. Carter, J.A. Deddens, B.M. Hurst, M.H. George and A.B. DeAngelo. A Two-Year Dose-Response Study of Lesion Sequences During Hepatocellular Carcinogenesis in the Male B6C3F1 Mouse Given the Drinking Water Chemical Dischloroacetic Acid. Environ. Health Perspectives, 111:53-64, 2003.

Snyder, R.D., S.J. Vogelpohl, B.L. Baldwin, E.D. Deaton, E. Baden and J.H. Carter, Apparent Inhibition of Apoptosis by Polyamines and Aminothiols in DNA Fragmentation Assays Is Artifactual. Cell Death & Differentiation 3:323-330, 1996. https://www.ncbi.nlm.nih.gov/pubmed/?term=snyder+apparent+inhibition+of+apoptosis

Richmond, R.E., J.H. Carter, H.W. Carter, F.B. Daniel and A.B. DeAngelo, Hepatocyte Expression of Tumor Associated Aldehyde Dehydrogenase and p21 Ras Following Diethylnitrosamine (DEN) Initiation and Chronic Exposure to Di(2-Ethylhexyl)Phthalate (DEHP). Carcinogenesis 17:1647-1655, 1996. https://academic.oup.com/carcin/article/17/8/1647/2475905?searchresult=1

Carter, J.H., H.W. Carter, A.B. DeAngelo, and F.B. Daniel, Biochemical, Pathologic and Morphometric Alterations Induced in Male B6C3F1 Mouse Liver by Short Term Exposure to Dichloroacetic Acid. Toxicol. Lett. 81:55-71, 1995. https://www.sciencedirect.com/science/article/abs/pii/0378427495034099

Richmond, R.E., J.H. Carter, H.W. Carter, F.B. Daniel and A.B. DeAngelo, Immunohistochemical Analysis of Dichloroacetic Acid (DCA)-induced Hepatocarcinogenesis in Male Fischer (F344) Rats. Cancer Lett. 92:67-76, 1995. https://www.sciencedirect.com/science/article/abs/pii/0304383594037569

Snyder, R.D., Pullman, J., Carter, J.H., Carter, H.W. and DeAngelo, A.B., In Vivo Administration of Dichloroacetic Acid Suppresses Spontaneous Apoptosis in Murine Hepatocytes. Cancer Research 55:3702-3705, 1995.
http://cancerres.aacrjournals.org/content/55/17/3702.full.pdf+html

Carter, J.H., R.E. Richmond, H.W. Carter, C.L. Potter, F.B. Daniel, and A.B. DeAngelo, Quantitative Image Cytometry of Hepatocytes Expressing Gammaglutamyl Transpeptidase and Glutathione S-Transferase in Diethylnitrosamine Initiated Rats Treated with Phenobarbital and/or Phthalate Esters, J. Histochem. & Cytochem. 40:1105-1115, 1992. https://journals.sagepub.com/doi/pdf/10.1177/40.8.1352315

Carter, J.H. and H.W. Carter, Adrenal Regulation of Mammary Tumorigenesis in Female Sprague-Dawley Rats: Histopathology of Mammary Tumors, Cancer Research 48:3808-3815, 1988.
http://cancerres.aacrjournals.org/content/48/13/3808.full.pdf+html

Carter, J.H., H.W. Carter, and J. Meade, Adrenal Regulation of Mammary Tumorigenesis in Female Sprague-Dawley Rats: Incidence, Latency and Yield of Mammary Tumors, Cancer Research 48:3801-3807, 1988.
http://cancerres.aacrjournals.org/content/48/13/3801.full.pdf+html

Richmond, R.E., M.A. Pereira, J.H. Carter, H.W. Carter, and R.E. Long, Quantitative and Qualitative Immunohistochemical Detection of Myc and Src Oncogene Proteins in Normal, Nodule, and Neoplastic Rat Liver, J. Histochem. & Cytochem. 36:179-184, 1988.