Research & Publications

Selected Publications from Our Laboratory

Peer-reviewed research spanning over three decades — advancing cancer diagnosis, prognosis, therapeutic targets, and understanding of environmental carcinogens.

Filter: 37 publications

Biomarkers & Prognosis

14 papers

2018 British Journal of Cancer Research Article

Transcription Factors WT1 and p53 Combined: A Prognostic Biomarker in Ovarian Cancer

Carter JH, Deddens JA, Mueller G, Lewis TG, Dooley MK, Robillard MC, Frydl M, Duvall L, Pemberton JO, Douglass LE

View Paper doi: 10.1038/s41416-018-0191-x

2016 Cancer Research Research Article

Stromal-Based Signatures for the Classification of Gastric Cancers

Uhlik MT, Liu J, Falcon BL, Lyer S, Stewart J, Celikkaya H, O'Mahony M, Sevinsky C, Lowes C, Douglass L, Jeffries C, Bodenmiller D, Chintharlapalli S, Fisch A, Gerald D, Xue Q, Lee J, Santamaria-Pang A, Al-Kofahi Y, Sui Y, Desai K, Doman T, Aggarwal A, Carter JH, Pytowski B, Jaminet S, Ginty F, Nasir A, Nagy JA, Dvorak HF, Benjamin LE

View Paper 76:2573–2586

2016 British Journal of Cancer Research Article

Phosphorylation of eIF4E Serine 209 is Associated with Tumor Progression and Reduced Survival in Malignant Melanoma

Carter JH, Deddens JA, Spaulding NR, Lucas D, Colligan BM, Lewis TG, Hawkins E, Jones J, Pemberton JO, Douglass LE, Graff JR

View Paper doi: 10.1038/bjc.2015.450

2013 Cancer Research Conference Abstract

Overexpression of PAK 1 is a Favorable Prognostic Biomarker in Malignant Melanoma

Carter JH, Spaulding NR, Colligan BM, Deddens JA, Douglass LE

doi: 10.1158/1538-7445.AM2013-22

2013 Cancer Research Conference Abstract

Prevalence of MET Expression, Activating Mutations of KRAS and IDH1/2, and ROS1 Fusions in Cholangiocarcinoma

Thobe MN, Yan SB, Credille KM, Nasir A, Roseberry Baker JA, Lajiness M, Brooks NA, Ballard DW, Farley DM, Peek VL, Um SL, Jin GJ, Gilmour R, Reinhard C, Graff JR, Schade AE, Gruver AM, Colligan BM, Douglass LE, Carter JH, Walgren RA

doi: 10.1158/1538-7445.AM2013-2339

2011 Cancer Research Conference Abstract

Overexpression of Cathepsin L is Associated with Prostate Cancer Development, Progression, and Reduced Patient Survival

Carter JH, Douglass LE, Deddens JA, Colligan BM, Hurst BM, Pullman J, Richmond RE, Carter HW

doi: 10.1158/1538-7445.AM2011-4172

2009 Cancer Research Research Article

eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival

Graff JR, Konicek BW, Lynch RL, Dumstorf CA, Dowless M, McNulty AM, Parsons S, Brail L, Colligan BM, Koop JW, Hurst BM, Deddens JA, Neubauer BL, Stancato LF, Carter HW, Douglass LE, Carter JH

View Paper 69(9):3866–73

2009 Cancer Research Conference Abstract

Translation Initiation Factor eIF4E Increases During Uterine Cervical Cancer Progression to Metastasis

Carter JH, Graff JR, Schaeper J, Nardini D, Love M, Colligan BM, Deddens JA, Douglass LE

69:5558

2009 Cancer Research Conference Abstract

β-Catenin in Human Colorectal Cancer Development, Progression, Metastasis and Survival

Douglass LE, Deddens JA, Colligan BM, Lucas D, Foertsch A, Graff JR, Carter JH

69:1652

2004 Clinical Cancer Research Research Article

Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis

Carter JH, Douglass LE, Deddens JA, Colligan BM, Bhatt TR, Pemberton JO, Konicek S, Hom J, Marshall M, Graff JR

View Paper 10:3448–3456

2001 Clinical Cancer Research Research Article

Expression of Group IIa Secretory Phospholipase A2 Increases with Prostate Tumor Grade

Graff JR, Konicek BW, Deddens JA, Chedid M, Hurst BM, Colligan BM, Neubauer BL, Carter HW, Carter JH

View Paper 7:3857–3861

2001 Clinical Cancer Research Research Article

Integrin-Linked Kinase Expression Increases with Prostate Tumor Grade

Graff JR, Deddens JA, Konicek BW, Colligan BM, Hurst BM, Carter HW, Carter JH

View Paper 7:1987–1991

1997 Clinical Cancer Research Research Article

Validation of the Galactose Oxidase–Schiff's Reagent Sequence for Early Detection and Prognosis in Human Colorectal Adenocarcinoma

Carter JH, Deddens JA, Pullman JL, Colligan BM, Whiteley LO, Carter HW

View Paper 3:1479–1489

1993 Laboratory Investigation Research Article

Immunohistochemical Detection of Ras, Jun, Fos and P53 Oncoprotein Expression in Human Colorectal Adenomas and Carcinomas

Richmond RE, Carter JH, Carter HW, Magrisso IJ, Pross C, Gilfillen R

69:674–681

Therapeutic Targets

4 papers

2017 Proc. Amer. Assoc. Cancer Res. Conference Paper

Evidence for WT1 as a Potential Target for Immunotherapy of Ovarian Cancer

Carter JH, Deddens JA, Muller G, Lewis TG, Dooley MK, Pemberton JO, Douglass LE

Vol. 58, pp. 712–713

2015 Cancer Research Conference Abstract

Targeting PAK 1 Activity in Breast Cancer: Inhibition of Cell Growth, Survival, Motility, and Signaling

Fajardo AM, Browne T, Graff H, Kleier K, Neltner K, McCall C, Meyer B, Douglass LE, Carter JH

doi: 10.1158/1538-7445.AM2015-1024

2008 Cancer Research Review Article

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

Graff JR, Konicek BW, Carter JH, Marcusson EG

View Paper 68(3):631–634

2007 Journal of Clinical Investigation Research Article

Therapeutic Suppression of Translation Initiation Factor eIF4E Expression Reduces Tumor Growth Without Toxicity

Graff JR, Konicek BW, Vincent TM, Lynch RL, Monteith D, Weir SN, Schwier P, Capen A, Goode RL, Dowless MS, Chen Y, Zhang H, Sissons S, Cox K, McNulty AM, Wang T, Sams L, Geeganage S, Douglass LE, Neubauer BL, Dean NM, Blanchard K, Shou J, Stancato LF, Carter JH, Marcusson EG

View Paper 117:2638–2648

Genetic Risk Factors

6 papers

2012 Cancer Research Conference Abstract

TGFβR1 Germline Variant Int7G24A but Not TGFβR1*6 Increases Risk for Colon Cancer

Carter JH, Murray K, Bender J, Restle H, Mulvihill S, Colligan BM, Deddens JA, Schaeper JP, Douglass LE

doi: 10.1158/1538-7445.AM2012-1153

2010 Cancer Research Conference Abstract

Association of Germline Variants of the TGFβR1 Gene in Colorectal Cancer Patients

Schaeper JP, Murray K, DeBrosse JL, Vogt B, Lucas D, Colligan BM, Deddens JA, Douglass LE, Graff JR, Carter JH

doi: 10.1158/1538-7445.AM10-1183

2009 Cancer Research Conference Abstract

Germline Homozygous TGFβR1 Variant Int7G24A Genotype is Significantly Related to Ovarian Cancer Progression

Schaeper JP, Chen T, Markey R, Shields K, Bree K, Kohrs B, Baldwin C, Colligan BM, Deddens JA, Graff JR, Douglass LE, Carter JH

69:5615

2006 Clinical Cancer Research Research Article

Int7G24 Variant of Transforming Growth Factor Beta Type 1 Receptor is Associated with Invasive Breast Cancer

Chen T, Jackson CR, Link A, Markey MP, Colligan BM, Douglass LE, Pemberton JO, Deddens JA, Graff JR, Carter JH

View Paper 12:392–397

2004 International Journal of Cancer Research Article

An Intronic Variant of the TGFBR1 Gene is Associated with Carcinomas of the Kidney and Bladder

Chen T, Jackson C, Costello B, Singer N, Colligan BM, Douglass LE, Pemberton JO, Deddens JA, Graff JR, Carter JH

View Paper 112:420–425

2001 Cancer Research Research Article

Transforming Growth Factor-β Receptor Type I Gene is Frequently Mutated in Ovarian Carcinomas

Chen T, Triplett J, Dehner B, Hurst B, Colligan BM, Pemberton JO, Graff JR, Carter JH

View Paper 61:4679–4682

Environmental Carcinogens

13 papers

2017 Toxicological Sciences Research Article

Metabolic Disruption Early in Life is Associated with Latent Carcinogenesis of Dichloroacetic Acid in Mice

Wehmas LC, DeAngelo AB, Hester SD, Chorley BN, Carswell G, Olson GR, George M, Carter JH, Eldridge SR, Fisher A, Vallanat B, Wood CE

doi: 10.1093/toxsci/kfx146

2014 Toxicological Sciences Research Article

Comparative Time Course Profiles of Phthalate Stereoisomers in Mice

Wood CE, Jokinen MP, Johnson CL, Olson GR, Hester S, George M, Chorley AN, Carswell G, Carter JH, Wood CR, Bhat VS, Corton JC, DeAngelo AB

View Paper 139:21–34

2014 Cancer Research Conference Abstract

Sub-Lethal Autolysis in Livers of Mice Given Phthalate Esters Precedes Development of Hepatic Lesions

Carter JH, Vogelpohl S, Tucker MK, Tagher R

doi: 10.1158/1538-7445.AM2014-3185

2010 Cancer Research Conference Abstract

Cell Proliferation and Apoptosis During Chloroform-Induced Hepatocarcinogenesis in Male F-344/N Rats

Carter JH, Carter HW, Richmond RE, Deddens JA, Chiu N, DeAngelo AB

doi: 10.1158/1538-7445.AM10-3451

2003 Environmental Health Perspectives Research Article

A Two-Year Dose-Response Study of Lesion Sequences During Hepatocellular Carcinogenesis in the Male B6C3F1 Mouse Given Dichloroacetic Acid

Carter JH, Carter HW, Deddens JA, Hurst BM, George MH, DeAngelo AB

111:53–64

1996 Cell Death & Differentiation Research Article

Apparent Inhibition of Apoptosis by Polyamines and Aminothiols in DNA Fragmentation Assays Is Artifactual

Snyder RD, Vogelpohl SJ, Baldwin BL, Deaton ED, Baden E, Carter JH

View Paper 3:323–330

1996 Carcinogenesis Research Article

Hepatocyte Expression of Tumor Associated Aldehyde Dehydrogenase and p21 Ras Following DEN Initiation and Chronic Exposure to DEHP

Richmond RE, Carter JH, Carter HW, Daniel FB, DeAngelo AB

View Paper 17:1647–1655

1995 Toxicology Letters Research Article

Biochemical, Pathologic and Morphometric Alterations Induced in Male B6C3F1 Mouse Liver by Short Term Exposure to Dichloroacetic Acid

Carter JH, Carter HW, DeAngelo AB, Daniel FB

View Paper 81:55–71

1995 Cancer Letters Research Article

Immunohistochemical Analysis of DCA-Induced Hepatocarcinogenesis in Male Fischer (F344) Rats

Richmond RE, Carter JH, Carter HW, Daniel FB, DeAngelo AB

View Paper 92:67–76

1995 Cancer Research Research Article

In Vivo Administration of Dichloroacetic Acid Suppresses Spontaneous Apoptosis in Murine Hepatocytes

Snyder RD, Pullman J, Carter JH, Carter HW, DeAngelo AB

View Paper 55:3702–3705

1992 J. Histochem. & Cytochem. Research Article

Quantitative Image Cytometry of Hepatocytes Expressing GGT and GST in DEN-Initiated Rats Treated with Phenobarbital and/or Phthalate Esters

Carter JH, Richmond RE, Carter HW, Potter CL, Daniel FB, DeAngelo AB

View Paper 40:1105–1115

1988 Cancer Research Research Article

Adrenal Regulation of Mammary Tumorigenesis in Female Sprague-Dawley Rats: Histopathology of Mammary Tumors

Carter JH, Carter HW

View Paper 48:3808–3815

1988 Cancer Research Research Article

Adrenal Regulation of Mammary Tumorigenesis in Female Sprague-Dawley Rats: Incidence, Latency and Yield

Carter JH, Carter HW, Meade J

View Paper 48:3801–3807

1988 J. Histochem. & Cytochem. Research Article

Quantitative and Qualitative Immunohistochemical Detection of Myc and Src Oncogene Proteins in Normal, Nodule, and Neoplastic Rat Liver

Richmond RE, Pereira MA, Carter JH, Carter HW, Long RE

36:179–184

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